Mangiferin enhances the antifungal activities of caspofungin by destroying polyamine accumulation
نویسندگان
چکیده
The incidence of fungal infections has increased continuously in recent years. Caspofungin (CAS) is one the first-line drugs for treatment systemic infection. However, emerging...
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متن کاملHepatic uptake of the novel antifungal agent caspofungin.
Caspofungin (CANCIDAS, a registered trademark of Merck & Co., Inc.) is a novel echinocandin antifungal agent used in the treatment of esophageal and invasive candidiases, invasive aspergillosis, and neutropenia. Available data suggest that the liver is a key organ responsible for caspofungin elimination in rodents and humans. Caspofungin is primarily eliminated by metabolic transformation; howe...
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ژورنال
عنوان ژورنال: Virulence
سال: 2021
ISSN: ['2150-5594', '2150-5608']
DOI: https://doi.org/10.1080/21505594.2020.1870079